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Back from Metabolomics 2018!

PREMIER Biosoft at Metabolomics 2018

July 03, 2018

PPREMIER Biosoft is back from 14th Annual Conference of the Metabolomics Society, Seattle Washington. It was great seeing you all there!

We showcased SimLipid® – a high throughput lipid characterization software, and SimMet® – A high throughput metabolite analysis software [...]

Tags: 14th International Conference of the Metabolomics Society, 2018 Metabolomics Conference

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Bioinformatics for Lipidomics: Keeping Up with The New MS Based Lipidomics Workflows with MS/MS Data Acquired using Various DIA Techniques

DIA for Shotgun lipidomics workflow

June 26, 2018

The rapid advancement in mass spectrometry (MS) technology led to the development of new lipidomics workflows. Recently, vendors manufacturing mass spectrometers have introduced various MS-based lipidomics workflows with MS/MS acquired using data-independent acquisition (DIA) approaches. The DIA-MS/MS methodology has been enabled on (Q)TOF - Waters Corporation, MSE, Agilent Technologies, All Ions MS/MS, SCIEX, Infusion MS/MSALL and Orbital ion trap - Thermo Fisher Scientific; All Ion Fragmentation-instruments [...]

Tags: Data Independent Acquisition, Ion Mobility Mass Spectrometry

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Meet Us @ Metabolomics 2018 Seattle, Washington

Meet PREMIER Biosoft at ASMS 2018, San Diego CA, June 3-7, 2018

June 15, 2018

We are pleased to announce that PREMIER Biosoft is participating in the 14th Annual Conference of the Metabolomics Society, Washington State Convention Center, from June 24-28, 2018 in Seattle, Washington.

We are showcasing SimLipid® – our high throughput lipid characterization and quantitation software, and SimMet® – A high throughput metabolite analysis software [...]

Tags: 2018 Metabolomics Conference, Metabolomics 2018

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Thank You for Joining Us @ASMS 2018!

Meet PREMIER Biosoft at ASMS 2018, San Diego CA, June 3-7, 2018

June 08, 2018

PREMIER Biosoft is back from 66th ASMS Conference on Mass Spectrometry and Allied Topics, San Diego CA, USA. It was wonderful seeing you all there! We showcased our software tools, namely, SimLipid® – a high throughput lipid characterization software, and SimGlycan® – a high throughput glycan & glycopeptide identification software. During the five-day event, we participated in multiple events organized in collaboration with our partner companies. Here are the highlights [...]

Tags: 66th ASMS Conference on Mass Spectrometry and Allied Topics 2018

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Meet Us @ ASMS 2018

Meet PREMIER Biosoft at ASMS 2018, San Diego CA, June 3-7, 2018

May 14, 2018

We are excited to announce that we are participating in the 66th ASMS Conference on Mass Spectrometry and Allied Topics at San Diego Convention Center from June 3 – 7, 2018, San Diego CA USA.

We are showcasing SimLipid® - Our high throughput lipid characterization software, and SimGlycan® - A high throughput glycan & glycopeptide identification software.

We are participating in multiple events organized by our partner companies. The events are as follows [...]

Tags: 66th ASMS Conference on Mass Spectrometry and Allied Topics 2018

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Bioinformatics Tool for Mass Spectrometry Based Lipidomics Workflows

Bioinformatics Tool for Mass Spectrometry Based Lipidomics Workflows

April 26, 2018

The main biological functions of lipids include energy storage, acting as structural components of cell membranes, and participating as important signaling molecules. Lipids play diverse and important roles in nutrition and health e.g., abnormal levels of certain lipids, particularly cholesterol, and trans fatty acids are risk factors for heart disease and other diseases. Lipids also play a key role in cell, tissue and organ physiology with diseases such as cancer and diabetes which involve disruption of metabolic enzyme pathways [...]

View the list of MS based lipidomics workflows supported by SimLipid software.

Tags: MS Based Lipidomics Workflows, Lipidomics Software

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Automating Rapid and Accurate Identification of the N-Glycans of a Recombinant Human Erythropoietin (rhEPO) Expressed by a Chinese hamster Ovary (CHO) Cell Line using Tandem MS/MS Data

Typical native N-Linked Glycans of rhEPO expressed by CHO cell line (Szabo et al. Journal of proteome research. 2018 Feb 16.)

March 27, 2018

Biopharmaceuticals represent the fastest growing sector of the pharmaceutical industry, mainly driven by a rapid expansion in the manufacture of recombinant protein-based drugs [1]. The majority of the therapeutic proteins are glycoproteins (monoclonal antibodies, blood proteins, growth factors, vaccines, fusion proteins) and hence, glycosylation is the most prominent post-translational modifications occurring on these protein drugs.
List of N-Glycans of CHO Cell Lines [...]

Tags: Identification of N-glycans of rhEPO Expressed by CHO Cell Line, Glycan Identification using LC-MS Methods with SimGlycan Software

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Back from APA 2018

PREMIER Biosoft at APA India 2018 Conference

March 01, 2018

PREMIER Biosoft is back from the Applied Pharmaceutical Analysis-India (APA) 2018 Conference held at The Westin, Pune, Koregaon Park, India from February 26-27, 2018. We showcased SimGlycan® software – a novel software solution for facilitating high throughput qualitative, and quantitative analysis of glycans in complex biological samples using mass spectrometry data [...]

Tags: APA India 2018, APA India 2018 Conference

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PREMIER Biosoft @ Applied Pharmaceutical Analysis-India (APA) 2018 Conference at Pune, India

APA India 2018

February 19, 2018

We are pleased to announce that PREMIER Biosoft is participating in the Applied Pharmaceutical Analysis-India (APA) 2018 Conference at The Westin, Pune, Koregaon Park, India from February 26-27, 2018.

Our Chief Scientific Officer, Dr. Sanjib N. Meitei, will be presenting a poster titled, "Automated Identification and Quantitation of Stable Isotope Labeled Released N-Glycans by LC-MS with SimGlycan software" at the conference organized by the Boston Society [...]

Tags: APA India 2018, N-Glycan Quantitation

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Automated and Rapid Characterization of Low-Molecular-Weight Heparin Oligosaccharides using SimGlycan software v. 5.90

LC-MS/MS Data Analysis for Low-Molecular-Weight Heparin Identification

February 15, 2018

Unfractionated Heparin (UH) is an anticoagulant formulated of anionic, sulfated glycosaminoglycan. However, during infusion, this naturally occurring anticoagulant has been associated with various health problems. In contrast, low molecular weight heparins (LMWH) such as Enoxaparin, Parnaparin, Certoparin, Deltaparin, etc., are relatively efficient and safer. Therefore, an increasing demand to study these LMWH as new regulatory drugs has been on the rise [...]

Tags: Identification of Low-Molecular Weight Heparin, SCIEX TripleTOF 5600 Mass Spectrometer, Unfractionated Heparin, LC-MS/MS Glycomic Data Analysis

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LC-MS Based Glycomics Analysis using Orbitrap-based Mass Spectrometers with SimGlycan Software

LC-MS Glycomics Analysis by SimGlycan

November 28, 2017

The separation of glycans by chromatography prior to MS analysis can reduce sample complexity, minimize ion suppression and increase dynamic range and separation of structural isomers. Rapid development in mixed-mode columns and faster scanning in high resolution mass spectrometers has increased the number of glycans resolved and identified by LC-MS. However, these advancements have not only lead to large data sets, but have also resulted in complex datasets [...]

Tags: LC-MS Glycomics Analysis, Glycan Workflow Solutions, MS/MS Data Analysis, Thermo Scientific™ Orbitrap Fusion™ Tribrid™ mass spectrometer

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Thank You for Joining Us @SFG 2017!

Thank you for joining us @SFG 2017!

November 13, 2017

PREMIER Biosoft is back from the Society for Glycobiology 2017 Annual Meeting held at Portland Oregon, USA. We showcased SimGlycan® software– our high throughput glycan and glycopeptide identification software which uses mass spectrometry data. A live demo of SimGlycan software was organized demonstrating the qualitative and quantitative glycomic data analysis workflows [...]

Tags: SFG 2017 Annual Meeting, Society For Glycobiology Meeting, SFG Portland, Oregon

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Hear Our Talk @SFG 2017 Annual Meeting Portland, Oregon

Talk @ SFG 2017 Annual Meeting Portland, Oregon

October 31, 2017

We are pleased to announce that PREMIER Biosoft is participating in the SFG 2017 Annual Meeting at Portland Oregon, USA from November 5-8, 2017.

We will be showcasing SimGlycan® software– our high throughput glycan and glycopeptide identification software which uses mass spectrometry data. We have recently released SimGlycan v. 5.80, which now offers improved and more accurate assignment of precursor m/z values of MS/MS scans by identifying isotope clusters from MS1 data [...]

Tags: SFG 2017 Annual Meeting, Glycomics Workflow Solutions, Biopharma, Glycan Analysis, Glycan Quantitation, Glycan Isotopic Labeling

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Shotgun Lipidomics of Prostate Cancer Cells using Shimadzu LC/MS 8050 Triple Quadrupole Mass Spectrometer and Simplified Data Analysis by SimLipid® Software

Shotgun Lipidomics of prostate cancer cells

September 20, 2017

Lipidomics is an emerging field in biomedical research as lipids play an important role in cell, tissue and organ physiology and have potential as biomarkers of disease or treatment success. Lipidomics has also been widely studied in many areas including prostate cancer research, e.g., identification of lipid species in bio-fluids as biomarkers in diagnosis of prostate cancer with high sensitivity [...]

Tags: Shotgun Lipidomics, Lipidomics Analysis Software, Lipid Quantitation, Shimadzu LC/MS 8050 triple quadrupole mass spectrometer, Precursor Ion/Neutral Loss scanning (PIS/NLS) experiments, Prostrate cancer lipidomics analysis, High throughput lipidomic data analysis software

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An Integrated Workflow for Profiling and Semi-Quantitative Analysis of Lipids using Agilent 1260 Infinity SFC Coupled with a 6545 LC/QTOF High Resolution Mass Spectrometer with SimLipid® Software

Learn Profiling and Semi-Quantitative Analysis of Lipids using SimLipid Software

August 04, 2017

The lipidome covers a range of lipids from non-polar to polar. Profiling experiments often need two or more chromatography separation schemes to cover the range of polarities: a normal phase method and a reverse phase method. Quantitation of the annotated lipids requires investigation using a more targeted approach. We have described a comprehensive analytical method using supercritical fluid chromatography (SFC) coupled to high resolution mass spectrometry for the analysis of lipids covering the whole spectrum of lipid classes in a single run [...]

Tags: LC-MS Lipid Data Processing Software, Semi-Quantitative Analysis of Lipids, Quantitative Analysis of Lipids, Supercritical Fluid Chromatography Workflows, Agilent 6545 Q-TOF LC/MS System, SPLASH™ Lipidomix® Mass Spec Standard, LC-MS Lipidomics Analysis, MS/MS Data Independent Acquisition

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PREMIER Biosoft @ Metabolomics 2017 Brisbane, Australia

PREMIER Biosoft Participated in Metabolomics 2017 Brisbane, Australia

July 05, 2017

PREMIER Biosoft is back from the 13th Annual Conference of the Metabolomics Society, Brisbane, Australia. We showcased SimLipid® – a high throughput lipid identification, and quantitation software using LC-, MALDI-, Direct infusion-, MS, MS/MS, SONAR™, HDMSE, MSE, MPIS/NLS data.

We interacted with eminent scientists and many research laboratories which were looking for a software solution to automate their mass spectrometry lipidomic data analysis workflows. We provided live demo of SimLipid software, answered various questions on lipid MS data processing tool, and distributed free trial licenses [...]

Tags: Metabolomics 2017, Waters UPLC SONAR Data Analysis Software, Waters UPLC HDMSE Data Analysis Software, Lipid MS Data Processing Software, Shotgun Lipidomics Software, DIA Data Analysis, Lipidomics MS Data Analysis

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Meet Us @ Metabolomics 2017 Brisbane, Australia

Meet PREMIER Biosoft @ Metabolomics 2017 Brisbane, Australia June 25-29, 2017

June 19, 2017

We are pleased to announce that PREMIER Biosoft is participating in the 13th Annual Conference of the Metabolomics Society, Brisbane Convention & Exhibition Center, from June 25-29, 2017, Brisbane, Australia.

We will be showcasing SimLipid® – our high throughput lipid characterization software. We have just released SimLipid v. 6.00, the first ever software platform for automated lipidomic data analysis [...]

Tags: Metabolomics 2017, Waters UPLC SONAR Data Analysis Software, Waters UPLC HDMSE Data Analysis Software, Lipid MS Data Processing Software, Shotgun Lipidomics Software, DIA Data Analysis, Lipidomics MS Data Analysis

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PREMIER Biosoft @ 65th ASMS, Indianapolis, IN, USA

PREMIER Biosoft @ 65th Annual Conference on Mass Spectrometry and Applied Topics (ASMS)

June 14, 2017

PREMIER Biosoft is back from 65th Annual Conference on Mass Spectrometry and Applied Topics (ASMS), Indianapolis, IN, USA. It was a wonderful experience! We showcased our software tools, namely, SimGlycan® – a high throughput glycan & glycopeptide identification software, and SimLipid® – a high throughput lipid characterization software. During the four-day event, we participated in multiple events organized by our partner companies [...]

Tags: ASMS 2017, Waters UPLC-SONAR Data Analysis Software, Lipid MS Data Processing Software, Shotgun Lipidomics Software, DIA Data Analysis, Differential Analysis, Glycomics MS Data Analysis

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Meet Us @ ASMS 2017 Indianapolis, IN, June 4-8, 2017

Meet PREMIER Biosoft at ASMS 2017 Indianapolis, IN, June 4-8, 2017

May 25, 2017

We are pleased to announce that PREMIER Biosoft is participating in the 65th Annual Conference on Mass Spectrometry and Applied Topics (ASMS), Indiana Convention Center, from June 4-8, 2017, Indianapolis, IN, USA.

We are showcasing –SimGlycan® – our high throughput glycan & glycopeptide identification software and SimLipid® – our high throughput lipid characterization software [...]

Tags: ASMS 2017, Waters UPLC-SONAR Data Analysis Software, Lipid MS Data Processing Software, Shotgun Lipidomics Software, DIA Data Analysis, Differential Analysis, Glycomics MS Data Analysis

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Automating Untargeted and Targeted LC-MS Lipid Data Analysis with SimLipid® Software

Automating Untargeted and Targeted LC-MS Lipid Data Analysis with SimLipid

May 22, 2017

The presence of lipids in membranes, or as signaling molecules, is reflective of the physiological state of an organism at a given time. Comparative studies of the complex lipid mixtures found in cells and tissues could potentially reveal lipid biomarkers. It may be noted that a single analytical method to screen all lipids in a biological system has yet to be developed. Targeted and non-targeted approaches based on chromatography and mass spectrometry have been employed for such studies and they both involve the identification and measurement of lipids in the sample [...]

Tags: Lipidomics Software, LC-MS Lipidomics Analysis, Bruker’s UHR-QqTOF MS, Impact II™

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PREMIER Biosoft Wins Second Prize at APA – India 2017

PREMIER Biosoft Wins Second Prize at APA – India 2017

February 22, 2017

PREMIER Biosoft participated in Applied Pharmaceutical Analysis 2017 Conference (APA - India 2017), February 19-21, at Crowne Plaza Ahmedabad City Centre, India. Organized by the Boston Society, many leading scientists and experts participated in this conference to learn best practices in Bioanalysis, Biotransformation and Drug Discovery Strategies through a series of short courses, poster presentations, lectures, interactive sessions and panel discussions [...]

Tags: Structural Identification of Unknown Glycans, Low Molecular Weight Heparins (LMWH), High-throughput Glycan Search

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Automate Shotgun, LC-MS and MALDI-MS Based High-throughput Lipidomics using SimLipid®

Automate Shotgun, LC-MS and MALDI-MS based high-throughput lipidomics usin SimLipid®

February 10, 2017

A combination of different approaches namely ‘Shotgun lipidomics’, LC-MS, and MALDI-TOF is often necessary to detect the whole lipidome of an organism. Each lipid class has its own fragmentation patterns as well as ionization efficiency [1], thereby making the interpretation of MS/MS lipid spectra a challenging task. Currently available software tools lack the ability to analyze data generated by all the mentioned approaches in a single platform. We have developed SimLipid® software to address this challenge [...]

Tags: Shotgun Lipidomics, High-throughput Lipidomics, Lipid Structural Elucidation

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