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SimGlycan®

Robust Glycan and Glycopeptide Database

SimGlycan®database is a large relational database containing 9,964 glycans, 22,814 glycoproteins*, 6,826 glycans with known biological sources and 5,874 glycans with known classes. The database is continuously updated as information on additional glycans is published.

*The glycoproteins have been curated from The UniProt Consortium.
UniProt: a hub for protein information
Nucleic Acids Res. 43: D204-D212 (2015)


Total number of glycans: 9,964
Major Biological Sources Number of Glycans
Human Blood Serum 58
Human IgG 71
Monoclonal Antibody (mAb) 71
Bovine Fetuin N-Glycans 71
Chinese hamster Ovary (CHO) N-Glycans 130
Polysaccharides from plants 210
Low Molecular Weight heparin (LMWH) 317
 
   

MS/MS Database
41,261,010 structure specific in-silico MS/MS fragments ions
Adducts:
Positive: H+, Na+, Li+, K+, Mg2+, NH4+
Negative: Formate (HCOO-)
Multiple adduct combinations such as [M+H+Na], [M+H+Li] etc.
Reducing end Fluorophore: 2-AB, 2-AA, RapiFluor-MS, aminoxyTMT6, Pa, Abee, Abhe, Abdeae, Tfan, Acp, Bap, Ant, Aga, Aba, and other custom fluorophore
Permethylation
Dual modification: 2-AA + Methylamidation of Sialic acid residues, Custom fluorophore combinations
 

 

* Indicates mandatory




Posters and Presentations

Automated and Rapid Characterization of Low-Molecular-Weight Heparin Oligosaccharides Using TripleTOF 5600 Mass Spectrometer...

SimGlycan: Informatics Support for Automated Characterization of Low-Molecular-Weight...
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Application Notes

A Unique Workflow for Glycoprotein Characterization from Sample Preparation to MS/MS Spectral Interpretation

Albanese, J., Lee, R. (2011)
J Biomol Tech., 22(Suppl), S57
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