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Citations and Reviews

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Szabo, Z., Thayer, J. R., Agroskin, Y., Lin, S., Liu, Y., Srinivasan, K., Saba, J., Viner, R., Huhmer, A., Rohrer, J. and Reusch, D. (2017). In-depth analyses of native N-linked glycans facilitated by high-performance anion exchange chromatography-pulsed amperometric detection coupled to mass spectrometry. Analytical and Bioanalytical Chemistry, pp.1-13. View Research Article/Paper
Wang, Z., Lorin, C., Koutsoukos, M., Franco, D., Bayat, B., Zhang, Y., Carfi, A., Barnett, S.W. and Porter, F. (2016). Comprehensive Characterization of Reference Standard Lots of HIV-1 Subtype C Gp120 Proteins for Clinical Trials in Southern African Regions. Vaccines, 4(2), p.17. View Research Article/Paper
Meitei, N. S., Apte, A., Snovida, S.I., Rogers, J.C., Saba, J. (2015). Automating Mass Spectrometry-Based Quantitative Glycomics using Aminoxy Tandem Mass Tag Reagents with SimGlycan. Journal of Proteomics. doi:10.1016/j.jprot.2015.05.015 View Research Article/Paper
Yang JM, Ai J, Bao Y, Yuan Z, Qin Y, Xie YW, Tao D, Fu D, Peng 2. (2014). Investigation of the correlation between charge and glycosylation of IgG1 variants by liquid chromatography–mass spectrometry. Anal Biochem PMID: 24287081 View Research Article/Paper
Udayananth Aich , Deanna C. Hurum, Lipika Basumallick , Srinivasa Rao, Chris Pohl, Jeffrey S. Rohrer, Sebastian Kandzia (2014). Evaluation of desialylation during 2-amino benzamide labeling of asparagine-linked oligosaccharides. PMID: 24657360 View Research Article/Paper
Mindy Porterfield, Peng Zhao, Haiyong Han, John Cunningham, Kazuhiro Aoki, Daniel D. Von Hoff, Michael J. Demeure, J. Michael Pierce, Michael Tiemeyer and Lance Wells (2014). Discrimination between Adenocarcinoma and Normal Pancreatic Ductal Fluid by Proteomic and Glycomic Analysis. Proteome Res., 2014, 13 (2), pp 395–407 DOI: 10.1021/pr400422g View Research Article/Paper
Tsai, Y.M., Hsu, S.C., Zhang, J., Zhou, Y.F., Plunkett, B., Huang, S.K., & Gao, P.S. (2013). Functional interaction of cockroach allergens and mannose receptor (CD206) in human circulating fibrocytes. PLoS ONE, 8(5). View Research Article/Paper
Strum, J.S., Nwosu, C.C., Hua, S., Kronewitter, S.R., Seipert, R.R., Bachelor, R.J., An, H.J., & Lebrilla, C.B. (2013). Automated assignments of N- and O-site specific glycosylation with extensive glycan heterogeneity of glycoprotein mixtures. Anal Chem., 85(12), 5666-5675. View Research Article/Paper
Woodin, C.L., Maxon, M., & Desaire, H. (2013) Software for automated interpretation of mass spectrometry data from glycans and glycopeptides. Analyst, 138(10), 2793-2803 View Research Article/Paper
Schiel, J.E., Au, J., He, H.J., & Phinney, K.W. (2012). LC-MS/MS biopharmaceutical glycoanalysis: identification of desirable reference material characteristics. Anal Bioanal Chem., 403(8), 2279-2289. View Research Article/Paper
Saba, J. (2012). Accelerating Glycan Characterization: New Workflow Brings Together Multistage Mass Spec and Data Processing to Speed Analysis. Genetic Engineering & Biotechnology News, 32(10). View Research Article/Paper
Jaiswal, N., Saraswat, S., Ratnam, M., & Isailovic, D. (2012). Analysis of folate binding protein N-linked glycans by mass spectrometry. J Proteome Res., 11(3), 1551-1560. View Research Article/Paper
Balonova, L., Hernychova, L., Stulik, J., Toman, R., Butaye, P., & Ulrich, R.G. (2011). Analysis of Francisella Tularensis Glycoproteins, in BSL3 and BSL4 Agents: Proteomics, Glycomics and Antigenicity. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527638192.ch6 View Research Article/Paper
Dixon, R.B., Bereman, M.S., Petitte, J.N., Hawkridge, A.M., & Muddiman, D.C. (2011). One-Year Plasma N-linked Glycome Intra-individual and Inter-individual Variability in the Chicken Model of Spontaneous Ovarian Adenocarcinoma. Int J Mass Spectrom., 305(2-3), 79-86. View Research Article/Paper
Böcker, S., Kehr, B., & Rasche, F.(2011). Determination of glycan structure from tandem mass spectra. IEEE/ACM Trans Comput Biol Bioinform., 8(4), 976-986. View Research Article/Paper
Leymarie, N., McComb, M.E., Naimy, H., Staples, G.O., & Zaia, J. (2012). Differential Characterization and Classification of Tissue Specific Glycosaminoglycans by Tandem Mass Spectrometry and Statistical Methods. Int J Mass Spectrom, 312, 144-154. View Research Article/Paper
Drake, R.R., Cazares, L.H., Jones, E.E., Fuller, T.W., Semmes, O.J., & Laronga, C. (2011). Challenges to developing proteomic-based breast cancer diagnostics. OMICS, 15(5), 251-259. View Research Article/Paper
Bereman, M.S., & Muddiman, D.C.(2011). N-linked global glycan profiling by nanoLC mass spectrometry. Methods Mol Biol, 790, 87-97. View Research Article/Paper
Prohaska, S.J., & Stadler, P.F. (2011) The use and abuse of -omes. Methods Mol Biol., 719, 173-196. View Research Article/Paper
Apte, A., & Meitei, N. S. (2010). Bioinformatics in glycomics: Glycan characterization with mass spectrometric data using SimGlycan™. In Functional Glycomics (pp. 269-281). Humana Press. View Research Article/Paper
Xie, H., Chakraborty, A., Ahn, J., Yu, Y.Q., Dakshinamoorthy, D.P., Gilar, M., Chen, W., Skilton, S.J., & Mazzeo, J.R.(2010). Rapid comparison of a candidate biosimilar to an innovator monoclonal antibody with advanced liquid chromatography and mass spectrometry technologies. MAbs., 2(4). View Research Article/Paper
White, K.Y., Rodemich, L., Nyalwidhe, J.O., Comunale, M.A., Clements, M.A., Lance, R.S., Schellhammer, P.F., Mehta, A.S., Semmes, O.J., & Drake, R.R. (2009) Glycomic characterization of prostate-specific antigen and prostatic acid phosphatase in prostate cancer and benign disease seminal plasma fluids.J Proteome Res., 8(2), 620-630. View Research Article/Paper
Bereman, M.S., Williams, T.I., & Muddiman, D.C.(2009). Development of a nanoLC LTQ orbitrap mass spectrometric method for profiling glycans derived from plasma from healthy, benign tumor control, and epithelial ovarian cancer patients. Anal Chem., 81(3), 1130-1136. View Research Article/Paper
Blow, N. (2009). Glycobiology: A spoonful of sugar. Nature,457(7229), 617-620. View Research Article/Paper

An Innovative Glycan and Glycopeptide MSn Data Analysis Tool SimGlycan® predicts the structure of glycans and glycopeptides using mass spectrometry data.

SimGlycan® accepts the experimental MS/MS and Multi Stage/Sequential mass spectrometry (MSn, n>2) data, matches them with its own database of theoretical fragments and generates a list of probable candidate structures. Each structure is scored to reflect how closely it matches your experimental data. Apart from the structural information, other biological information for the probable molecular structures such as the glycan class (N-Linked, O-Linked heparin, lipopolysaccharide etc.), reaction, pathway and enzyme are also made available for easy reference in case of structural elucidation of glycans while in the case of glycopeptide qualitative analysis, information such as Protein ID, Protein Name, Source, Classification, Class, peptide sequence, peptide mass etc. are made available for identified glycopeptides.

Glycan & Glycopeptide MS/MS Data Analysis for Studying Glycosylation

Protein Glycosylation, which is a key post-translational modification, is the result of addition of a glycan to a peptide sequence. Glycopeptides are known to exhibit multiple biological functions. In order to identify distinct functional properties for defined structural features, detailed information on the respective glycan moieties is essential. In order to understand all these phenomena, glycosylation analysis is an area of growing interest. Glycans have also been found to participate in many biological processes including embryonic development, inter and intracellular activities, coordination of immune functions, pathogens homing on their host tissues, cell division processes and protein regulations and interactions.


  • Robust Glycan and Glycopeptide Database
  • Support for MALDI MS/MS and LC-MS/MS Workflows
  • Data Input File Formats
  • Accurate Ranking Mechanism
  • Additional Filters For Precise Results
  • Comprehensive Result Analysis
  • LC-MS and LC- MS/MS Data Processing
  • High Throughput Analysis
  • TMT Quantitation
  • Multi Stage Mass Spectrometry (MSn) Data Analysis
  • Glycopeptide Qualitative Analysis
  • Project Management
  • Draw Glycans
  • Mass Spectra Interpretation


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