Whole Genome Array Design with Array Designer; Easy and Fast
Array Designer can be used to interrogate a gene/an exon or any other stretch of DNA of your choice. Here are the options available for whole genome array design that Array Designer presents:
- Probes for Equal Sized Fragments: The program divides the entire genome into equal sized fragments and designs probes for each one of them.
- Probes by Annotations: This option helps you design probes for each exon or gene. The genes/exons are resolved using GenBank file annotations or can be specified manually.
What are Whole Genome Arrays?
Whole genome array experiments use array-based hybridization to scan the entire genome of an organism. The technology helps investigate expression levels of all genes, transcripts or a large fraction of the genome simultaneously with high reproducibility and sensitivity. This is achieved by using a set of overlapping oligonucleotide probes covering the entire genome.
The development of whole genome array represents another advancement critical to the development of new microarraying applications. Whole genome arrays have been useful for studying the poorly understood aspects of trancriptomes and natural antisense transcripts as they can simultaneously monitor gene expression on both strands of the genome. They have been found extremely useful for discovering novel genes.