Untargeted and Targeted Lipidomics Using Ultra-High Resolution Qq-Time-Of-Flight Impact II™ Mass Spectrometer with SimLipid® Software

Improvements in analytical methods, especially liquid chromatography and mass spectrometry, have driven the recent advances in the development of lipid profiling methods. We have presented a robust workflow for the global lipid profiling of a plasma sample using an LC system coupled to an Impact II™ Ultra-High Resolution Qq-Time-Of-Flight (UHR-QqTOF) mass spectrometer (Bruker Daltonik, Bremen, Germany) with > 50,000 Full-Sensitivity Resolution and SimLipid® informatics software (PREMIER Biosoft, USA).

Meitei N.S., Gupta H., Apte, A., Barsch, A., Alving, A., PREMIER Biosoft & Bruker Daltonik (2016)

PREMIER Biosoft Technical Note No. TSL101

Phospholipid analysis using SimLipid software

Phospholipids (PLs) have a role of constituting a cellular membrane in a living cell and are also related to produce various fatty acids such as arachidonic acids, EPA and DHA which are precursors of bioactive lipids. Fluctuation of PLs concentration in a blood or a tissue is also known to be correlated with various disease.

T. Nakanishi (2017)

Shimadzu Document No. LAAN-A-LM-E120